منابع مشابه
High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients
High levels of low-density lipoprotein cholesterol (LDL-C) enhance platelet activation, whereas high levels of high-density lipoprotein cholesterol (HDL-C) exert a cardioprotective effect. However, the effects on platelet activation of high levels of LDL-C combined with low levels of HDL-C (HLC) have not yet been reported. We aimed to evaluate the platelet activation marker of HLC patients and ...
متن کاملImplication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, wais...
متن کاملVery low LDL‐C levels may safely provide additional clinical cardiovascular benefit: the evidence to date
BACKGROUND Cardiovascular disease (CVD) is the leading cause of death in Europe and increased low-density lipoprotein cholesterol (LDL-C) is a major contributor to CVD risk. Extensive evidence from clinical studies of statins has demonstrated a linear relationship between LDL-C levels and CVD risk. It has been proposed that lower LDL-C levels than those currently recommended may provide additio...
متن کاملSweetless'n low LDL-C targets for PCSK9 treatment.
In their trial, Cannon et al. report the superiority of the anti-PCSK9 monoclonal antibody (mAb) alirocumab (SAR236553/REGN727; s.c. 75 mg every 2 weeks) over ezetimibe (oral 10 mg once a day) in the reduction of LDL-cholesterol (LDL-C) levels among 720 patients athigh cardiovascular risk whowere inadequately controlled despite maximally tolerated statin dosage. At week 24, mean reduction in LD...
متن کاملThe effect of decreasing statin's dosage on LDL-C levels after target levels achieved.
OBJECTIVE Evidences from clinical trials had demonstrated that statins reduce the risk of cardio-cerebral vascular events. But lipid lowering therapy (LLT) was suboptimal in stroke patients and clinically, observation of reducing the dosage of statins is common when target low density lipoprotein cholesterol (LDL-C) level achieved. We aim to explore the changes in lipid profile after reducing s...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2020
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2020.03.040